liftsiron
Owner/Admin
- Joined
- Nov 12, 2003
- Messages
- 19,015
Posted by jboldman on SBI
DHEA and fat loss
This international journal talks about the different pathways and benefits of dhea and test regarding fat burning.
jb
=========================================
Int J Obes Relat Metab Disord 2000 Jun;24 Suppl 2:S59-63 Related Articles, Links
The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone.
De Pergola G.
Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche dell'Universita di Bari, Policlinico di Bari, Italy. [email protected]
Testosterone (T) and dehydroepiandrosterone (DHEA) are fat-reducing hormones, even though they exert this effect by different mechanisms. In particular, T inhibits lipid uptake and lipoprotein-lipase (LDL) activity in adipocytes, and stimulates lipolysis by increasing the number of lipolytic beta-adrenergic receptors. An indirect sign of these effects is the decrease of adipocyte leptin production. Lastly, T inhibits differentiation of adipocyte precursor cells. Concerning DHEA, this hormone does not seen to have any of T effects; however, DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane. The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin. Noteworthy, the fat-reducing effect of both T and DHEA seems to be more evident at the level of visceral adipose tissue.
DHEA and fat loss
This international journal talks about the different pathways and benefits of dhea and test regarding fat burning.
jb
=========================================
Int J Obes Relat Metab Disord 2000 Jun;24 Suppl 2:S59-63 Related Articles, Links
The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone.
De Pergola G.
Istituto di Clinica Medica, Endocrinologia e Malattie Metaboliche dell'Universita di Bari, Policlinico di Bari, Italy. [email protected]
Testosterone (T) and dehydroepiandrosterone (DHEA) are fat-reducing hormones, even though they exert this effect by different mechanisms. In particular, T inhibits lipid uptake and lipoprotein-lipase (LDL) activity in adipocytes, and stimulates lipolysis by increasing the number of lipolytic beta-adrenergic receptors. An indirect sign of these effects is the decrease of adipocyte leptin production. Lastly, T inhibits differentiation of adipocyte precursor cells. Concerning DHEA, this hormone does not seen to have any of T effects; however, DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane. The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin. Noteworthy, the fat-reducing effect of both T and DHEA seems to be more evident at the level of visceral adipose tissue.
