Im well into my 40's and no prob with tren, but only tren e, with test of course and will use some mast as well. Current: Androlic 50mg up to 75mg in wk 2, Tren 300mg/Mast 300mg Karachi 750mg. All depends on individual and how well you take care of yourself and supplement maintainence. I take red yeast rice 1200mg ed for cholesterol, apple cider vinegar mixed w/4oz of orange Chrystal Lite at night, 600mg-1200mg Saw Palmetto for prostate, Liv-52 for liver detox. Also take multi, liquid BCAA's twice daily, proten shakes of course, extra zinc, magnesium, and vit-c. Drink plenty of water. Regular sex will help regulate prostate as well.