Im well into my 40's and no prob with tren, but only tren e, with test of course and will use some mast as well.  Current: Androlic 50mg up to 75mg in wk 2, Tren 300mg/Mast 300mg  Karachi 750mg.  All depends on individual and how well you take care of yourself and supplement maintainence.  I take red yeast rice 1200mg ed for cholesterol, apple cider vinegar mixed w/4oz of orange Chrystal Lite at night,  600mg-1200mg Saw Palmetto for prostate, Liv-52 for liver detox.  Also take multi, liquid BCAA's twice daily, proten shakes of course, extra zinc, magnesium, and vit-c.  Drink plenty of water.  Regular sex will help regulate prostate as well.